Publications

Norton EM, Plumb S, Shane D, et al. Leucine, pyridoxine and resveratrol supplementation alter metabolic parameters in ponies with equine metabolic syndrome. Equine Vet J. 2025. https://doi.org/10.1002/evj.70135.
 

Rebello CJ, Zemel MB, Kolterman O, Fleming GA, Greenway FL. Leucine and sildenafil combination therapy reduces body weight and metformin enhances the effect at low dose: a randomized controlled trial. Am J Ther. 2021;28(1):p e1-e13. https://doi.org/10.1097/MJT.0000000000001303.

Zemel MB. Modulation of energy sensing by leucine synergy with natural sirtuin activators: effects on health span. J Med Food. 2020;23(11). https://doi.org/10.1089/jmf.2020.010.

Murphy M, Bartges JW, Zemel MB, Kirk CA, Witzel-Rollins A. Effect of a leucine/pyridoxine nutraceutical on caloric intake and body composition of obese dogs losing weight. Front Vet Sci. 2020;7. https://doi.org/10.3389/fvets.2020.00555.

Zemel MB, Kolterman O, Rinella M, et al. Randomized controlled trial of a leucine-metformin-sildenafil combination (NS-0200) on weight and metabolic parameters. Obesity. 2019;27:59-67. https://doi.org/10.1002/oby.22346.

Banerjee J, Bruckbauer A, Thorpe T, Zemel MB. Biphasic effect of sildenafil on energy sensing is mediated by phosphodiesterases 2 and 3 in adipocytes and hepatocytes. Int J Mol Sci. 2019;20(12):2992. https://doi.org/10.3390/ijms20122992.

 
Chalasani N, Vuppalanchi R, Rinella M, et al. Randomised clinical trial: a leucine-metformin-sildenafil combination (NS-0200) vs placebo in patients with non-alcoholic fatty liver disease. Aliment Pharmacol Ther. 2018;47(12):1639-1651. https://doi.org/10.1111/apt.14674.
 
Bruckbauer A, Banerjee J, Fu L, et al. A combination of leucine, metformin, and sildenafil treats nonalcoholic fatty liver disease and steatohepatitis in mice. Int J Hepatol. 2016. https://doi.org/10.1155/2016/9185987.

Banerjee J, Bruckbauer A, Zemel MB. Activation of the AMPK/Sirt1 pathway by a leucine–metformin combination increases insulin sensitivity in skeletal muscle, and stimulates glucose and lipid metabolism and increases life span in Caenorhabditis elegans. Metabolism. 2016;65(11):1679-1691. https://doi.org/10.1016/j.metabol.2016.06.011.

Fu L, Bruckbauer A, Li F, et al. Leucine amplifies the effects of metformin on insulin sensitivity and glycemic control in diet-induced obese mice. Metabolism. 2015;64(7):845-56. https:/doi.org/10.1016/j.metabol.2015.03.007.

Fu L, Li F, Bruckbauer A, et al. Interaction between leucine and phosphodiesterase 5 inhibition in modulating insulin sensitivity and lipid metabolism. Diabetes Metab Syndr Obes. 2015;8:227–239. https://doi.org/10.2147/DMSO.S82338.

Bruckbauer A, Zemel MB. (2015). Leucine and resveratrol: experimental model of sirtuin pathway activation. In: Rajendram R., Preedy V, Patel V. (eds) Branched Chain Amino Acids in Clinical Nutrition. New York, NY: Nutrition and Health. Humana Press. https://doi.org/10.1007/978-1-4939-1923-9_8.

Fu L, Bruckbauer A, Li F, et al. Interaction between metformin and leucine in reducing hyperlipidemia and hepatic lipid accumulation in diet-induced obese mice. Metabolism. 2015;64(11):1426-34. https://doi.org/10.1016/j.metabol.2015.07.006.

Liang C, Curry BJ, Brown PL, Zemel MB. Leucine modulates mitochondrial biogenesis and SIRT1-AMPK signaling in C2C12 myotubes. J Nutr Metab. 2014:239750. https://doi.org/10.1155/2014/239750.

Zemel MB, Bruckbauer A. Effects of a leucine and pyridoxine-containing nutraceutical on body weight and composition in obese subjects. Diabetes Metab Syndr Obes. 2013;23;6:309-315. https://doi.org/10.2147/DMSO.S49623.

Zemel MB, Bruckbauer A. Effects of a leucine and pyridoxine-containing nutraceutical on fat oxidation, and oxidative and inflammatory stress in overweight and obese subjects. Nutrients. 2012;4(6):529-541. https://doi.org/10.3390/nu4060529.